Tracking stem cells

Heart-related diseases are the leading cause of death in the industrialized world. Cardiac stem cell therapy is a promising new way of reducing those numbers, but its application has proven to be less effective than hoped. Now researchers at Stanford University have developed nanoparticles that can be used to image stem cells implanted into the heart. They claim this will help improve the efficiency of these transplants drastically.

Doctors track stem cells with nanoparticles during cardiac therapy,  Ars Technica, 22 March 2013.

Image credit: trialx.com

What intellectually stimulating conversations look like

Nicholas Taleb’s Reddit AMA has been, by far, the most intellectually stimulating “ask me anything” that I’ve ever read. I don’t agree with everything that he says (see last question below, for example). Nevertheless the whole thread was thoroughly enjoyable. Here are excerpts of bits that made me pause and think:

R: What kind of risks do you think we overlook most in day to day life?

T: The answer to your question is in the following: 7000 Americans die every day, many, many of preventable causes. What we talk about is usually the sensational. Do the math: they die from lack of stressors (activity), corn syrup, cigarettes, etc. So the real risks/killers are discernible; they map to the risks for your life.

R: Is your freedom the only source to go on fighting with such fervor?

T: I have always been fighting… But my freedom gives me more moral obligations, make me feel more guilt for not shouting fraud when I see it.

R: What kind of system would you set up in order to promote anti-fragility?

T: Rule: any company that would cause a national emergency requiring a bailout should it fail should be classified BAILABLE-OUT and employees should not be allowed to earn more than civil servants. That would force companies to 1) be small, 2) not leech off the taxpayer.

R: What is the most important skill or trait a human being can have in the modern world?

T: A sense of honor. It puts you above everything else.

R: What is one thing that a recent college graduate can due to be Antifragile?

T: Get passing grades and follow voraciously your curiosity on the side instead of competing in school. In the end what matters is your curiosity, nothing else. And read nothing that doesn’t interest you but interests someone else.

R: You’ve talked a lot about financial issues and health issues. You have touched on the environment, but not said much about energy use.

T: The problem is the nonlinearity of harm. We have too many people on the planet, with too much concentration of pollutants. And these people are converging to the same habits.. We are not supposed to be eating the same thing. Any concentration harms.

R: What can the average joe do to make sure “skin in the game” is enforced on those in power?

T: Decentralization is where we start. Vote for that and for people promoting it.

R: What have you been reading recently?

R: You can check out his amazon reviews if you haven’t seen that yet. Link

R: How many books in your library have you not read?

T: Actually, only 40% partially read.

R: Can you begin to be antifragile while being poor or you should first make some money and plan ahead?

T: The poor is more antifragile than the rich: less to lose, both economically and psychologically.

R: As an engineer and technologist, I’m exposed to a lot of neophilia. Do you have any suggestions for heuristics besides reading the classics as an inoculation against neophilia?

T: Yes, use the Lindy effect as a testing rule… that is, look for solutions from simpler technologies.

The longer a technology has been around, the longer it’s likely to stay around.

R: according to your principles, how would you deal with the obesity epidemic hitting the U.S.?

T: The general problem is that we are not made to control our environment, and we are designed for a degree of variability: in energy, temperature, food composition, sleep duration, exercise (by Jensen’s inequality). Depriving anyone of variations is silly. So we need to force periods of starvation/fasts , sleep deprivation , protein deprivation, etc. Religions force shabbats, fasts, etc. but we are no longer under the sway of religions… The solution is rules…

Social entrepreneurs in India: Water for all

Nearly three-fourths of all diseases caused in India are due to water contaminants. Despite that, one in eight Indians still lacks access to clean drinking water. The poor now realise that paying for clean water can save much more in health-care costs later. It was this market that Sarvajal, a social enterprise in India, wanted to cater to.

Founded in 2008, Sarvajal—which in Sanskrit means “water for all”—now sells clean drinking water to more than 70,000 people in rural India. In bigger villages, it employs local people to man filtration plants and sell water. In small villages it installs solar-powered water dispensing machines (pictured) that use prepaid (or pay-as-you-go) smart cards that can be topped up just like a mobile phone. The machines send data to a central server via SMS, which helps Sarvajal ensure regular supply of clean water.

Sarvajal started with some help from the Piramal Foundation, a charity. And it is not alone: Water Health International was launched with an investment from the Acumen Fund and the Naandi Foundation’s not-for-profit company was backed by a charity with the same name. What sets Sarvajal apart is that it has stayed away from government subsidies while still keeping the price of water low. It sells 10 litres of water for four pence (or six cents), just as much or lower than its competitors.

“Subsidies are not a long-term solution,” says Anand Shah, Savajal’s founder, who grew up in America and moved to India to become a social entrepreneur. It took a healthy bit of tinkering to lower the price of installation and maintenance for its water supply infrastructure. It costs on average $2,500 to install a filtration plant, which is about half the expense of similar projects. Sarvajal claims to recover those costs within three years.

Setting up its project was not easy. Savajal needed to deal with things that few businesses in rich countries have to worry about: lack of proper roads in villages, irregularity of power supply, unreliability of water sources and devising a system of money transfer. Having reached a respectable size, Mr Shah is hopeful that scaling up his business further will be less challenging.

Apart from villages, Sarvajal’s other obvious market is the urban poor. Nearly 100m people live in very densely populated slums in India’s cities. They are more willing to pay a higher price for water than villagers who have a much smaller disposable income. But Mr Shah says that “water barons”, sellers of bottled-water, have been trying to block Sarvajal’s entry into cities. After many months of efforts, this time not without help from the government, Sarvajal will soon be launching its first filtration plant in Delhi.

First published on economist.com.

Image credit: Sarvajal