Why there may be fewer truly new drugs hitting the market

Developing new drugs is hard and expensive. The lengthy process from initial discovery to the market is some times compared to the difficulty of putting a person on the moon. Despite accusations that the pharma industry is evil, the real reason could be summarised pithily in what one scientist said: “Drugs are expensive because we are stupid.”

Even after studying some diseases for more than 100 years, we are not close to understanding them well enough. With so many unknown factors at play, the fact that we are able to still find relatively simple chemicals to effectively act as drugs is pretty amazing.

But with much initial success, the productivity of the pharma industry has been falling for many decades. According to John LaMattina, former president of global research and development at Pfizer, “30 is the new 50” in the drug industry. He is referring to the number of new drugs approved per year, which has been on average declining since the 1960s. This is happening at the same time as research and development (R&D) costs are going up.

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Finding the true cost of a new drug is a complex and controversial exercise. However, one acceptable way to calculate it is to divide total R&D spend of pharma companies by the number of new drugs produced. Because of differences in agreeing what constitutes R&D spend, even this measure produces only a range – the cost of a new drug is somewhere between US$1 billion and US$5 billion.

However, many argue that simply looking at the rising costs does not give the true measure of the pharma industry’s productivity. New drugs don’t always mean effective new treatments. According to new studies just published in the Journal of the American Medical Association (JAMA), Efthimios Parasidis of Ohio State University writes on The Conversation that nearly half of the new drugs between 2005 and 2011 received an approval without the drug company needing to show that those drugs had any tangible benefit to a patient.

With rising costs and fewer new drugs, the pharma industry could do with a boost in the arm. That, however, seems to be a hard find.The Conversation

First published on The Conversation.

Solar wind and space dust create new source of water

Water ice is the most abundant solid material in the universe. Much of it was created as the byproduct of star formation, but not all. John Bradley of Lawrence Livermore National Laboratory and his team may have discovered a new source of water in our solar system. His lab experiments reveal that the solar wind may be creating water on interplanetary dust.

The sun ejects high-speed charged particles in all directions. Bodies in the inner solar system get bombarded by this wind of particles, which continuously varies in intensity.

Small bodies, such as dust particles or tiny asteroids, can be eroded by these harsh winds. Larger bodies that do not have an atmosphere, such as the Moon, are bombarded by both the solar wind and tiny meteorites. This form of bombardment causes a phenomenon called space weathering. (Atmospheres protect planets from tiny meteorites, while a magnetic field can deflect solar winds.)

The lunar dust brought back by the Apollo missions showed for the first time the result of space weathering—though not immediately. A careful examination of the dust returned from the lunar surface had to wait until the 1990s when scientific instruments became good enough. When finally observed under sufficiently powerful microscopes, the dust particles revealed what have been called “rims.”

These dust particles are usually made of silicates—compounds of silicon, oxygen, hydrogen and few metallic elements. The rims are the result of chemical modification of the surface of the particle, caused by high energy impacts and the continuous bombardment of the solar wind.

The modification leads to an imbalance in the chemical structure of the particle, sometimes loosening the bonds holding oxygen and hydrogen atoms in the silicates. This made scientists speculate that there is a chance that water could be formed somewhere in these rims .

Water needs two atoms of hydrogen and one of oxygen. If silicates provide one atom of each element, then only one more hydrogen atom is needed. Conveniently, hydrogen atoms are available in abundance in the solar wind, where they are found as high-energy protons (hydrogen atoms stripped off their electrons). If the conditions are right, this charged hydrogen atom can react on a dust particle’s rim to form water.

Plausible as this seems, past attempts to find water on these rims gave mixed results. The problem was that the reactions were happening at such tiny scales, and instruments weren’t good enough to unambiguously detect water.

That’s where Bradley’s work comes in. The team attempted to locate water using a highly-sensitive method of analysis called valence electron energy-loss spectroscopy. The method involves exposing a sample to a beam of electrons that, on hitting the material, will get deflected at different speeds. The deflection and the speeds can reveal how much energy was lost by the electrons in the process, which is based on the type of atom it hits. The instrument can identify the composition of a material at very small scales, just enough for Bradley to analyse silicate rims.

The best way to determine whether water forms on silicate rims is to do these experiments on the types of silicate material that exist in space. Bradley did this by using three types of these minerals: olivine, clinopyroxene, and anorthine. These were exposed to charged hydrogen and helium particles, which were a proxy for the solar wind.

If water is formed by the solar wind, it would only be found in the samples that were exposed to hydrogen—not in those exposed to helium. And that is what happened. As reported in PNAS, Bradley’s sensitive tests repeatedly found water, but only in the samples that were bombarded by hydrogen.

Martin McCoustra at Heriot-Watt University in Edinburgh finds the work convincing. He said: “I am not very surprised that water could be formed on silicates. However, now that they have shown that it can, it could be an important source of water.”

Bradley’s work implies that water molecules must have been forming for billions of years on interplanetary dust particles, on the Moon, and possibly on asteroids. However, McCoustra warns that “This source of water, albeit new, won’t be able to account for a large proportion of water in the solar system. Most of that water was formed during the process of star formation that our sun went through.”

Some have argued that water-rich comets planted water on our planet. But McCoustra reckons that a single-source is unlikely. And this study provides another potential source for the material that helps make our planet habitable.The Conversation

PNAS, 2013. DOI: 10.1073/pnas.1320115111First published at The Conversation.

Ten tiny places that have their own domain names

Claiming to be a country is an easy task. But to make others accept your claim is a lot harder. Aspiring states need favours from great powers, or sometimes even celebrities, to establish their legitimacy. In the digital age, this starts with wanting a top-level domain name, such as the “.in” suffix for India.

The Scottish National Party, which is rooting for Scotland’s separation from the UK in a referendum to be held this year, launched a campaign in 2008 to get Scotland its own top-level domain name. After five years, the International Corporation for Assigned Names and Numbers (ICANN), a consortium that controls these suffixes, agreed to setup the “.scot” suffix.

As Nina Caspersen, who studies the politics of unrecognised states at the University of York, wrote on The Conversation this week, states such as Somaliland and Transnistria start by setting up websites where they claim to be “independent and democratic”. However, with websites ending in “.com” or “.org”, respectively, their claims look weak.

These countries would have had better luck had they been dependent regions to start with, because ICANN assigns domain names to dependent regions if they apply. That is why, although there are the 206 sovereign states (of which 11 are not recognised by the United Nations), there are 255 country-code domain names.

This can go too far. For example, Heard and McDonald Islands, a dependency of Australia in the Indian Ocean, has its own top-level domain name, “.hm”, even though its population is zero, and its official website uses Antarctica’s top-level domain name, “.aq”. And it’s not alone.

Here is a list of the ten least populated regions with their own top-level domain name:

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First published at The Conversation.The Conversation